中國藥科大學

金亮，男，1975年9月9日出生，教授，博士生導師。2006年畢業(yè)于中國藥科大學微生物與生化藥學專業(yè)，獲博士學位，后留校任講師；2010年5月晉升為副教授；2010年7月至2013年12月，在美國希望之城國家醫(yī)學中心(National Medical Center)從事博士后研究工作；2014年1月被中國藥科大學特聘為教授。近5年來主持國家‘863’計劃項目1項（立項），國家自然科學基金面上項目1項，國家自然科學基金青年基金1項，江蘇省杰出青年基金1項，中央高校基礎科研基金2項，并作為主要負責人（第二負責人）主持美國NIH基金項目（R01,125萬美金）1項。近年在國際權威雜志發(fā)表了30多篇SCI收錄研究論文，包括Proc Natl Acad Sci USA，The journal of immunology，Stem Cells Dev，Endocrine-Related Cancer，Vaccine等雜志。其中以第一作者發(fā)表SCI論文8篇，累計影響因子超過40。

研究方向：1胰腺干細胞的篩選與分化

2脂肪干細胞的分化與應用

3腫瘤干細胞生物學

4重組蛋白及多肽類藥物研究

近5年主要科研成果：

第一作者論文：

1.Liang Jin, Tao Feng, Hung Ping Shih, Ricardo Zerda, Angela Luo, Jasper Hsu, Alborz Mahdavi, Maike Sander, David A. Tirrell, Arthur D. Riggs, and Hsun Teresa Ku*. Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel. Proc Natl Acad Sci USA; 2013, 110 (10) : 3907-3912, (IF:10.583).

2.Xianghui Fu, Liang Jin, Xichun Wang, Angela Luo, Junkai Hu, Xianwu Zheng, Walter M. Tsark, Arthur D. Riggs, H. Teresa Ku*. Wendong Huang; MiR-26a targets TET enzymes and is regulated during pancreatic cell differentiation. Proc Natl Acad Sci USA; 2013, 110 (44): 17892-17897, (Co-first author, IF: 10.583).

3.Liang Jin, Tao Feng, Ricardo Zerda, Ching-Cheng Chen, Arthur D. Riggs and Hsun Teresa Ku*. In vitro multi-lineage differentiation and self-renewal of single pancreatic colony-forming cells from adult C57Bl/6 mice; Stem Cells Dev; 2014, 23 (8): 899-909, (IF:4.67).

4.Liang Jin,Tao Feng, Jing Chai, Nadiah Ghazalli, Dan Gao, Ricardo Zerda, Zhuo Li,Jasper Hsu, Alborz Mahdavi, David A. Tirrell, Arthur D. Riggs,and Hsun Teresa Ku*. Colony-forming progenitor cells in the postnatal mouse liver and pancreas give rise to morphologically distinct insulin-expressing colonies in 3D cultures. Rev Diabet stud; 2014, 11(1):35-50, (IF:2.94).

5.Jin Liang, Zhu Aihua, Wang Yu, Lu Yong Liu Jingjing*. HSP65 serves as an immunogenic carrier for a diabetogenic peptide P277 inducing anti-inflammatory immune response in NOD mice by nasal administration. Vaccine; 2010, 28: 3312-33172, (IF:3.492).

6.Liang Jin, Aihua Zhu, Yu Wang, Qingmei Chen, Qiyan Xiong, Jianping Li, Yunxiao Sun, Taiming Li, Jie Wu, and Jingjing Liu*. A Th1 recognized peptide P277, when tandem repeated, induces a Th2 cytokine burst and toward effective vaccines against autoimmune diabetes in NOD mice. The journal of immunology; 2008, 180 (1): 58 – 63, (IF:5.79).

7.Jin Liang, Zhu aihua, Wang Yu, Liu JingJing*. Enhanced immunogenicity of peptide P277 by heat shock protein HSP65 vector carrying tandem repeats of P277 to prevent type 1 diabetes in NOD mice. Experimental and Clinical Endocrinology & Diabetes; 2008, 116 (9):1-8, (IF:1.555).

8.Jin Liang, Wang Yu, Xiong Qiyan, Chen Qingmei, Li Jianping, Zhu Aihua, Cao Rongyue, Wu Jie, Liu Jingjing Long-lasting specific antibodies against p277 induced by mucosal administration of p277 repeat sequences carried by Hsp65 in the absence of adjuvants. Vaccine; 2007 25: 2043-2050, (IF:3.492).

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